Bacterial vaginosis (BV) is the most common cause of abnormal vaginal discharge.1
Vaginal symptoms aren't always from a yeast infection. Learn the difference between common infections:
BV1
What it is:
An infection caused by overgrowth of certain bacteria naturally present in the vagina
  • Discharge that's thin and white or light gray
  • A fishy odor, especially after sex
  • Pain, itching or burning in or around the vagina (sometimes)
Many women with BV do not have any symptoms, or they may have discharge that comes and goes.1
Trichomoniasis (Trich)1
What it is:
A sexually transmitted infection (STI) caused by the parasite trichomonas vaginalis
  • Frothy vaginal discharge that's yellowish or greenish
  • Unpleasant odor
  • Itching and irritation (sometimes)
SOLOSEC also treats trich.2

Yeast Infection1
What it is:
An infection in and/or around the vagina caused by an overgrowth of fungus*
*SOLOSEC is not approved to treat yeast infections.
  • Thick, white vaginal discharge with a clumpy texture
  • No odor
  • Itching, irritation and pain, occasionally severe
Unlike a yeast infection, which is caused by a fungus and can be treated with over-the-counter medications, BV is caused by bacteria and must be treated with prescription antibiotics.3
BV is caused by an overgrowth of bacteria that are naturally present in the vagina1
Understanding Your Vagina's Natural Balance
Here's what makes you more likely to get BV
While any woman can get BV, certain risk factors can increase your chances:
  • Douching4
  • Smoking4
  • Being overweight or obese5
  • Having been pregnant in the past4
  • Sexual activity (being sexually active, higher number of lifetime sexual partners, and same-sex sexual activity)4
    • BV is not considered a sexually transmitted infection (STI), but women who are not sexually active rarely get BV.1
BV can have serious consequences if left untreated1
Research has shown that untreated or improperly treated BV is associated with increased risk of:
Research has shown that untreated or improperly treated BV is associated with increased risk of:
  • Getting STIs like HPV, herpes, trichomoniasis (trich), chlamydia, gonorrhea, and HIV1
  • Transmitting STIs to your partner1
  • Developing pelvic inflammatory disease (PID), which can threaten your fertility1
  • Complications with gynecological surgery1
Diagnosed with trich? SOLOSEC treats both BV and trich.2
Diagnosed with trich? SOLOSEC treats both BV and trich.2

  • If you're pregnant, it's especially important to get tested.
  • If left untreated, BV increases the risk of complications with your pregnancy, including late term miscarriage and premature birth.1,6

SOLOSEC has no pregnancy restrictions.2
  • Available data on pregnancy are limited to animal studies.
It's possible to have trich and BV at the same time7
Approximately
70%
of women with trich are also infected with the bacteria that cause BV.7

SOLOSEC is the only single dose oral antibiotic that's FDA-approved to treat both trich and BV.1
WHY SOLOSEC IS DIFFERENT
SOLOSEC is the only single dose oral antibiotic that's FDA-approved to treat both trich and BV.1
It's common for BV to come back1
For women who are treated with a common 7-day, twice-daily course of treatment:

  • Nearly half (43%)
    will experience a recurrence in 3 months.9
  • Over half (58%)
    will experience a recurrence within 1 year.9
Research shows that not taking the full course of 7-day treatment can contribute to BV coming back.10
 
The majority of women taking SOLOSEC needed no additional treatment for BV.11
References:
1. Workowski KA, Bachmann LH, Chan PA, et al. CDC Sexually Transmitted Diseases Treatment Guidelines, 2021. MMWR Recomm Rep 2021;70(RR-04):1-192. 2. SOLOSEC [Prescribing Information]. Evofem Biosciences, Inc.: San Diego, CA; October 2024. 3. CDC. Bacterial Vaginosis Fact Sheet. Updated Jun 2017. Accessed 26 Jul 2021.4. Koumans EH, Sternberg M, Bruce C, et al. The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis. 2007;34(11):864-869. 5. Brookheart RT, Lewis WG, Peipert JF, Lewis AL, Allsworth JE. Association between obesity and bacterial vaginosis as assessed by Nugent Score. Am J Obstet Gynecol. 2019;220(5):476.e1-476.e11. 6. Leitich H, Bodner-Adler B, Brunbauer M, et al. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis Am J Obstet Gynecol 2003;189(1):139-147 7. Sobel JD, Subramanian C, Foxman B, Fairfax M, Gygax S. Mixed Vaginitis—More than Coinfection and with Therapeutic Implications. Curr Infect Dis Rep 2013;15:104-108. 8. Brotman RM. Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective. J Clin Invest. 2011;121(12):4610-4617.9. Bradshaw CS, Morton AN, Hocking J, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006; 193:1478–89. 10. Marrazzo JM, Thomas KK, Fledler TL, Ringwood K, Fredricks DN. Relationship of Specific Vaginal Bacteria and Bacterial Vaginosis Treatment Failure in Women Who Have Sex with Women. Ann Intern Med 2008;149:20-28. 11. S Schwebke JR, Morgan FG Jr, Koltun W, Nyirjesy P. A phase-3, double-blind, placebo controlled study of the effectiveness and safety of single oral doses of secnidazole 2 g for the treatment of women with bacterial vaginosis [published correction appears in Am J Obstet Gynecol 2018;219(1):110]. Am J Obstet Gynecol 2017;217(6):678.e1-678.e9.
 

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What is SOLOSEC?

SOLOSEC® (secnidazole) 2g oral granules is a prescription medicine used to treat bacterial vaginosis in females 12 years of age and older. SOLOSEC is used to treat Trichomoniasis, a common sexually transmitted infection (STI), in people 12 years of age and older. People taking SOLOSEC for Trichomoniasis should avoid having sex until they and their sex partners are treated with the same dose and at the same time, to prevent reinfection. It is not known if SOLOSEC is safe and effective in children under 12 years of age.

How should I take SOLOSEC?

SOLOSEC is a single-dose therapy for oral use. Use SOLOSEC by sprinkling an entire packet of SOLOSEC onto applesauce, yogurt, or pudding. The entire dose should be taken at once, and finished within 30 minutes. Avoid chewing or crunching the granules. SOLOSEC should not be taken by dissolving the granules in any liquid. Avoid drinking alcohol during treatment with SOLOSEC and for 2 days (48 hours) after you take SOLOSEC.

Important Safety Information

  • You should not use SOLOSEC if you've had an allergic reaction to secnidazole, other ingredients of the formulation, or other nitroimidazole derivatives or have Cockayne syndrome.
  • Before taking SOLOSEC, tell your healthcare provider about all of your medical conditions, including if you
    • Are pregnant or plan to become pregnant.
    • Are breastfeeding or plan to breastfeed. Breastfeeding is not recommended. You should not breastfeed for 96 hours (4 days) after taking SOLOSEC.
  • Vaginal yeast infections may occur with SOLOSEC and require an antifungal treatment.
  • The most common side effects of SOLOSEC include headache, nausea, vomiting, diarrhea, abdominal pain, vaginal itching and a bad, bitter or metallic taste in your mouth (dysgeusia).
  • Take SOLOSEC exactly as your healthcare provider tells you to. Do not take SOLOSEC more often than it is prescribed.

Call your doctor for medical advice on side effects. You are encouraged to report suspected side effects of prescription drugs to FDA at www.fda.gov/MedWatch also at 1-800-FDA-1088 or contact Evofem Biosciences, Inc. at 1-833-EVFMBIO (1-833-383-6246).

Please see full prescribing information for SOLOSEC, available here.

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